Ultrasensitive Fluorescent miRNA Biosensor Based on a “Sandwich” Oligonucleotide Hybridization and Fluorescence Resonance Energy Transfer Process Using an Ln(III)-MOF and Ag Nanoparticles for Early Cancer Diagnosis: Application of Central Composite Design
Ahmad Afzalinia, Mahdi Mirzaee
Abstract
) or 5.5 fM of the miRNA-155 biomarker. Therefore, this biosensor provides highly promising potential for lung and breast cancer diagnosis.
Topics & Concepts
Förster resonance energy transferBiosensorMaterials scienceFluorescenceFourier transform infrared spectroscopyOligonucleotideNanoparticleAnalytical Chemistry (journal)NanotechnologyChemistryChromatographyChemical engineeringBiochemistryDNAEngineeringQuantum mechanicsPhysicsAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryMetal-Organic Frameworks: Synthesis and Applications