Screening for Cyclotides in Sri Lankan Medicinal Plants: Discovery, Characterization, and Bioactivity Screening of Cyclotides from <i>Geophila repens</i>
Sanjeevan Rajendran, Błażej Ślązak, Supun Mohotti, Taj Muhammad, Adam A. Strömstedt, Małgorzata Kapusta, Emilia Wilmowicz, Ulf Göransson, Chamari Hettiarachchi, Sunithi Gunasekera
Abstract
. Taken together with the cytotoxicity and membrane permeabilizing activities, this implicates gere cyclotides as potential plant defense molecules. The presence of cyO2-like gere 1 in a plant in the Rubiaceae supports the notion that phylogenetically distant plants may have coevolved to express similar cytotoxic cyclotides for a specific functional role, most likely involving host defense.
Topics & Concepts
BiologyCytotoxicityMedicinal plantsTraditional medicineBiochemistryBotanyIn vitroMedicineBiochemical and Structural CharacterizationPhytoplasmas and Hemiptera pathogensToxin Mechanisms and Immunotoxins