Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
Beatríz Sierra, Ana Beatriz Alvarez Pérez, E. Aguirre, Claudia Bracho, Odalys Valdés, Narciso Jiménez, Waldemar Baldoquín Rodríguez, Guelsys González, Lilia M Ortega, Maria Caridad Montalvo, Sonia Resik, Delmis Álvarez, María G. Guzmán
Abstract
Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19's pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.
Topics & Concepts
MedicineImmune systemCoronavirus disease 2019 (COVID-19)DiseaseImmunologyPathogenesisSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronavirusPredictive valueInternal medicineInfectious disease (medical specialty)COVID-19 Clinical Research StudiesRespiratory viral infections researchSARS-CoV-2 and COVID-19 Research