Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance
Qingxia Ma, Qianqian Xu, Jiaojiao Zhao, Wen‐Wei Zhang, Qiang Wang, Jing‐Yuan Fang, Zhimin Lu, Jia Liu, Leina Ma
Topics & Concepts
SorafenibMAPK/ERK pathwayHDAC4Cancer researchHepatocellular carcinomaApoptosisSignal transductionBiologyDownregulation and upregulationHistone deacetylaseCell biologyHistoneBiochemistryGeneHepatocellular Carcinoma Treatment and PrognosisCancer Mechanisms and TherapyKruppel-like factors research