Reaction of barbituric/thiobarbituric acid with phosphines or phosphites and dialkyl acetylenedicarboxylates for synthesis of phosphorus zwitterions or phosphonate derivatives
Mohammad Anary‐Abbasinejad, Fereshteh Nejad-Shahrokhabadi
Abstract
A three-component reaction between barbituric/thiobarbituric acid, phosphines, and dialkyl acetylenedicarboxylates in dry acetonitrile led to the formation of barbiturate/thiobarbiturate-functionalized stable zwitterionic salts in a one-pot process. When trialkyl phosphites were used instead of phosphines, barbiturate/thiobarbiturate-functionalized phosphonates were obtained in good yields.
Topics & Concepts
Barbituric acidChemistryPhosphonateBarbiturateAcetonitrileOrganic chemistryPhosphorusThiobarbituric acidMedicinal chemistryPolymer chemistryPsychologyLipid peroxidationAntioxidantPsychiatryPhosphorus compounds and reactionsOrganophosphorus compounds synthesisMulticomponent Synthesis of Heterocycles