Fabrication and characterization of a myrrh hydrocolloid dressing for dermal wound healing
Olatunji Ajiteru, Ok Joo Lee, Jung-Ho Kim, Young Jin Lee, Ji Seung Lee, Hanna Lee, Md. Tipu Sultan, Chan Hum Park
Abstract
Common occurrence of dermal injuries has made wound dressing a critical component in wound healing. Hydrocolloid wound dressings have been developed as fanciful and effective wound dressing with ability for wound fluid control, adherence to wound site, and infection prevention. Effectiveness of topical application of myrrh resin to dermal wound has been well documented. We fabricated Mirderm hydrocolloid wound dressings with myrrh resin to enhance wound healing and improve on the mechanical characteristics of the hydrocolloid. The biocompatibility of Mirderm was assayed with CCK-8 while the wound healing efficacy was tested in vivo. The physical and mechanical properties were checked to affirm the suitability of Mirderm as hydrocolloid wound dressing. We observed Mirderm showed superior wound healing and mechanical capability suitable for hydrocolloid polymer relative to investigated commercial hydrocolloid and medical Gauze. These are indications that Mirderm may be an improvement on standard dressings such as Gauze and some commercial hydrocolloids.