Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling
Evan R. Delgado, Hanna Erickson, Junyan Tao, Satdarshan P. Monga, Andrew W. Duncan, Sayeepriyadarshini Anakk
Abstract
does not alter β-catenin or MET activation; instead, it promotes YAP activity. Overall, we demonstrate that although IQGAP1 expression is not required for HCC development, the gain of IQGAP1 function promotes the rapid onset and increased liver carcinogenesis. Our results show that an adequate amount of IQGAP1 scaffold is necessary to maintain the quiescent status of the liver.
Topics & Concepts
IQGAP1CarcinogenesisScaffold proteinBiologyCancer researchHepatocellular carcinomaCell biologySignal transductionCell growthCancerGeneticsHippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathways