In Vivo Emergence of Pandrug-Resistant <i>Acinetobacter baumannii</i> Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
Mollie VanNatta, Laurie Grier, Muhammad Hamid Khan, Paulette Pinargote Cornejo, Mohammad Khursheed Alam, Samir H. Moussa, Jennifer Smith, Samuel L Aitken, Alexandre Malek
Abstract
Abstract The treatment of patients with infection secondary to carbapenem-resistant Acinetobacter baumannii with emerging cefiderocol resistance remains challenging and unclear. We present a case of in vivo emergence of pandrug-resistant A baumannii that was successfully treated with the compassionate use of investigational sulbactam-durlobactam–based antibiotic regimen. We also performed a longitudinal genomic analysis of the bacterial isolates and showed the development of resistance and genetic mutations over time.
Topics & Concepts
Acinetobacter baumanniiSulbactamMedicineMicrobiologyIn vivoDrug resistanceAntibiotic resistanceCephalosporinAntibioticsPseudomonas aeruginosaBiologyBacteriaGeneticsImipenemAntibiotic Resistance in BacteriaVibrio bacteria research studiesAntibiotic Use and Resistance