Advances in Biginelli reaction: A comprehensive review
Aravind Chandravarkar, Thaipparambil Aneeja, Gopinathan Anilkumar
Abstract
Abstract The Biginelli reaction, a conventional three‐component reaction provides 3,4‐dihydropyrimidin‐2(1H)‐ones/thiones via one‐pot acid catalyzed cyclocondensation of an aldehyde, a β‐keto ester, and urea or thiourea. Dihydropyrimidones are well‐known scaffolds having a wide range of pharmacological activities. So far classical Biginelli reaction has witnessed several modification and studies are still continuing in this field to develop greener and efficient methodologies. In this review, we summarize the recent advances in Biginelli reaction covering literature from 2020 to 2023.
Topics & Concepts
Biginelli reactionThioureaChemistryAldehydeUreaOrganic chemistryCatalysisCombinatorial chemistryMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Tetrazole Derivatives