A single phosphorylation mechanism in early metabolism – the case of phosphoenolpyruvate
Joris Zimmermann, Robert J. Mayer, Joseph Moran
Abstract
generated acyl phosphate subsequently undergoes an intramolecular phosphoryl transfer to yield PEP. A single phosphorylation mechanism acting on carboxylates appears sufficient to initiate metabolic networks that include PEP, strengthening the case that metabolism emerged from self-organized chemistry.
Topics & Concepts
Mechanism (biology)PhosphorylationPhosphoenolpyruvate carboxykinaseChemistryMetabolismBiochemistryCell biologyBiologyPhilosophyEnzymeEpistemologyOrigins and Evolution of LifeMitochondrial Function and PathologyEnzyme Structure and Function