Antisense Peptide Nucleic Acid–Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria
Mirko Iubatti, Isabel Maicas Gabas, Lina Cavaco, Elnaz Harifi Mood, Ernest Wee Kiat Lim, Federica Bonanno, Niloofar Yavari, Camilla Brolin, Peter E. Nielsen
Abstract
administration up to a dose of 20 mg/kg, and in vivo fluorescence imaging indicated clearance via renal excretion with slight accumulation in the kidneys and liver. Thus, DAB-based dendrons constitute a promising new chemistry platform for development of effective delivery agents for antibacterial drugs with possible in vivo use.
Topics & Concepts
In vivoAntimicrobialNucleic acidEscherichia coliPeptide nucleic acidAntibacterial activityAntibioticsMicrobiologyBacteriaChemistryDendrimerBiochemistryPharmacologyBiologyGeneBiotechnologyGeneticsAntimicrobial Peptides and ActivitiesAdvanced biosensing and bioanalysis techniquesBacteriophages and microbial interactions