Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis
Feng Yao, Wenbao Wang, Yan Zhang, Xuefeng Fu, Kunqi Ping, Jiaxing Zhao, Yu Lei, Yanhua Mou, Shaojie Wang
Topics & Concepts
CelastrolChemistryNecroptosisGliomaIC50CytotoxicityApoptosisCell cultureProgrammed cell deathIn vitroBiochemistryPharmacologyCancer researchBiologyGeneticsNatural Compounds in Disease TreatmentCell death mechanisms and regulationNatural product bioactivities and synthesis