Influenza A Virus-Induced circRNA circMerTK Negatively Regulates Innate Antiviral Responses
Haori Qiu, Bincai Yang, Yongqin David Chen, Qianwen Zhu, Faxin Wen, Min Peng, Guoqing Wang, Guijie Guo, Biao Chen, Mohamed Maarouf, Min Fang, Ji‐Long Chen
Abstract
. It was found that expression of 413 circRNAs was significantly altered, of which 171 were upregulated, and 242 were downregulated following the IAV infection. Interestingly, circMerTK was identified as a positive regulator of IAV replication in both human and mouse hosts. CircMerTK was shown to influence IFN-β production and its downstream signaling, enhancing IAV replication. This finding provides new insights into the critical roles of circRNAs in regulating antiviral immunity.
Topics & Concepts
BiologyVirologyVirusComputational biologyInfluenza A virusInfluenza pandemicmicroRNACoronavirus disease 2019 (COVID-19)GeneticsGeneMedicineDiseasePathologyInfectious disease (medical specialty)Circular RNAs in diseasesMicroRNA in disease regulationinterferon and immune responses