Cardiovascular Effects of Particulate Air Pollution
Aruni Bhatnagar
Abstract
Inhalation of fine particulate matter (PM 2.5 ), produced by the combustion of fossil fuels, is an important risk factor for cardiovascular disease. Exposure to PM 2.5 has been linked to increases in blood pressure, thrombosis, and insulin resistance. It also induces vascular injury and accelerates atherogenesis. Results from animal models corroborate epidemiological evidence and suggest that the cardiovascular effects of PM 2.5 may be attributable, in part, to oxidative stress, inflammation, and the activation of the autonomic nervous system. Although the underlying mechanisms remain unclear, there is robust evidence that long-term exposure to PM 2.5 is associated with premature mortality due to heart failure, stoke, and ischemic heart disease.