Nanotechnology-Based Nucleic Acid Vaccines for Treatment of Ovarian Cancer
Simav Gildiz, Tamara Minko
Abstract
Anticancer vaccines represent a promising approach for effective treatment of cancer and along with recent advantages of nucleic acid-based vaccines for other diseases form a prospective and potentially efficacious direction of the research, development and clinical applications. Despite the ongoing several clinical trials of mRNA vaccines for the treatment of various types of cancer, to-date no cancer vaccines were approved by the US Food and Drug Administration. The present review analyzes and summarizes major approaches for treating of different forms of ovarian cancer including mRNA-based vaccines as well as nanotechnology-based approaches for their delivery.
Topics & Concepts
Ovarian cancerClinical trialCancerMedicineFood and drug administrationNucleic acidPharmacologyBiologyInternal medicineBiochemistryImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryAnimal Virus Infections Studies