2‐Deoxy‐<scp>d</scp>‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in <scp>India</scp> against <scp>SARS‐CoV</scp>‐2
Enrique A. Mesri, Théodore J. Lampidis
Abstract
Mechanisms discovered to drive increased glucose metabolism in cancer cells are found to be similar to those in viral-infected cells. In this mini review, we summarize the major pathways by which the sugar analog, 2-Deoxy-d-glucose, has been shown to exploit increased glucose metabolism in cancer and how this information applies to viral-infected cells. Moreover, we highlight the relevance of these findings to the emergency approval of 2-Deoxy-d-glucose in India to be used against SARS-CoV-2, the virus responsible for COVID-19.
Topics & Concepts
Cancer cellCancerMetabolismCellular metabolismBiochemistryCarbohydrate metabolismSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyVirologyChemistryCoronavirus disease 2019 (COVID-19)Cell biologyMedicineGeneticsDiseaseInternal medicineInfectious disease (medical specialty)Liver Disease Diagnosis and TreatmentMetabolism, Diabetes, and CancerDiet, Metabolism, and Disease