The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis
Alexander J. Stemm-Wolf, Eileen O’Toole, Ryan M. Sheridan, Jacob T. Morgan, Chad G. Pearson
Abstract
, which encodes a major centriolar satellite protein and is required to organize the trafficking and MT network around the centrosomes. This study highlights the importance of the distinct MT trafficking network that is intimately associated with nascent centrioles and is responsible for procentriole development and efficient ciliogenesis.
Topics & Concepts
CiliogenesisCentrosomeCentrioleBiologyCell biologyRNA splicingSplicing factorGeneticsCiliumMicrotubuleRNAGeneCell cycleGenetic and Kidney Cyst DiseasesMicrotubule and mitosis dynamicsChromosomal and Genetic Variations