Organo-catalyzed asymmetric cascade annulation reaction for the construction of bi-spirocyclic pyrazolone and oxindole derivatives
Bingbing Sun, Jun‐Bo Chen, Jun‐Qi Zhang, Xiaopeng Yang, Hao-Peng Lv, Zheng Wang, Xing‐Wang Wang
Abstract
Organo-catalyzed tandem reaction between β,γ-unsaturated α-ketoesters and α-arylidene pyrazolinones was developed, and it provided chiral bi-spirocyclic pyrazolone and oxindole derivatives in high yields with good to excellent stereoselectivity.
Topics & Concepts
PyrazoloneChemistryOxindoleAnnulationStereoselectivityTandemCatalysisCascade reactionCascadePyrazolonesCombinatorial chemistryReaction conditionsOrganic chemistryMaterials scienceChromatographyComposite materialAsymmetric Synthesis and CatalysisSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions