Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
Yonglu Huang, Yuchen Wu, Chang Cai, Rong Zhang, Gongxiang Chen, Ning Dong
Abstract
We identified an ST133 extensively drug-resistant Enterobacter hormaechei , C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla KPC-2 and mcr-9.1 , and genes iutAiucABCD and iroBCDEN encoding the virulence factor, siderophores.
Topics & Concepts
VirulenceBiologyMicrobiologySiderophoreGalleria mellonellaGeneDrug resistanceGeneticsAntibiotic resistanceMultiple drug resistanceComparative genomicsGenomic islandEnterobacterAntibioticsGenomicsGenomeEscherichia coliAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsParasitic Infections and Diagnostics