Chronic intermittent hypoxia-induced mitochondrial dysfunction mediates endothelial injury via the TXNIP/NLRP3/IL-1β signaling pathway
Ya Ru Yan, Liu Zhang, Ying Ni Lin, Xian Wen Sun, Yong Ding, Ning Li, Hong Peng Li, Shi Qi Li, Jian Zhou, Qing Yun Li
Topics & Concepts
TXNIPEndothelial dysfunctionDownregulation and upregulationUmbilical veinOxidative stressApoptosisSignal transductionInflammationCell biologyMitochondrionHypoxia (environmental)MedicineBiologyEndocrinologyImmunologyChemistryIn vitroBiochemistryThioredoxinGeneOxygenOrganic chemistryObstructive Sleep Apnea ResearchHeme Oxygenase-1 and Carbon MonoxideInflammasome and immune disorders