Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
Shrilekha Chilvery, Sapana Bansod, Mohd Aslam Saifi, Chandraiah Godugu
Topics & Concepts
SMADHepatic stellate cellExtracellular matrixFibronectinEpithelial–mesenchymal transitionLiver injuryFibrosisChemistryDownregulation and upregulationOxidative stressCancer researchHepatic fibrosisTransforming growth factorSignal transductionPharmacologyMedicineInternal medicineBiochemistryGeneLiver physiology and pathologyDrug Transport and Resistance MechanismsLiver Disease and Transplantation