Litcius/Paper detail

Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration

Liang Yu, Lingjie Kong, Yuelu Zhang, Yihan Zhang, Mingsu Shi, Jiaqiu Huang, Hongyu Kong, Siyi Qi, Yunlong Yang, Jiaxu Hong, Meidong Zhu, Xiangjia Zhu, Xinghuai Sun, Shujie Zhang, Lianqun Wu, Chen Zhao

2024Theranostics18 citationsDOIOpen Access PDF

Abstract

This study demonstrated the important role of tRF-Glu-CTC in the progression of angiogenesis. Targeting of tRF-Glu-CTC may be an alternative to current anti-VEGF therapy for CNV in AMD and other conditions with angiogenesis.

Topics & Concepts

Macular degenerationChoroidal neovascularizationAngiogenesisCancer researchAngiogeninBiologyNeovascularizationMolecular biologyPathologyMedicineOphthalmologyCancer-related molecular mechanisms researchRNA modifications and cancerMicroRNA in disease regulation