Mechanism of action of nucleotide excision repair machinery
Areetha D'Souza, Alexandra M. Blee, Walter J. Chazin
Abstract
Nucleotide excision repair (NER) is a versatile DNA repair pathway essential for the removal of a broad spectrum of structurally diverse DNA lesions arising from a variety of sources, including UV irradiation and environmental toxins. Although the core factors and basic stages involved in NER have been identified, the mechanisms of the NER machinery are not well understood. This review summarizes our current understanding of the mechanisms and order of assembly in the core global genome (GG-NER) pathway.
Topics & Concepts
Nucleotide excision repairDNA repairDNADNA damageMechanism of actionChemistryCell biologyMechanism (biology)NucleotideComputational biologyBiologyGenomeGeneticsDNA mismatch repairBroad spectrumBase excision repairAction (physics)Core (optical fiber)MutationGeneDNA Repair MechanismsCancer-related Molecular PathwaysEpigenetics and DNA Methylation