Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
Samaa Saied, Moataz A. Shaldam, Mostafa M. Elbadawi, Simone Giovannuzzi, Alessio Nocentini, Hadia Almahli, Rofaida Salem, Tamer M. Ibrahim, Claudiu T. Supuran, Wagdy M. Eldehna
Topics & Concepts
ChemistryCarbonic anhydraseIn vitroGene isoformCancer cellDocking (animal)Cancer researchApoptosisVascular endothelial growth factorCarbonic anhydrase IICancerEnzymeVEGF receptorsBiochemistryGeneBiologyGeneticsNursingMedicineEnzyme function and inhibitionSynthesis and Catalytic ReactionsCoagulation, Bradykinin, Polyphosphates, and Angioedema