Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A
Ivanka Sevrieva, Saraswathi Ponnam, Ziqian Yan, Malcolm Irving, Thomas Kampourakis, Yin‐Biao Sun
Abstract
sensitivity and decreased cooperativity at both SLs, which may translate to deleterious effects in physiological settings. Our results could have clinical relevance for disease pathways, where PKA phosphorylation of cTnI may be functionally uncoupled from cMyBP-C phosphorylation due to mutations or haploinsufficiency.
Topics & Concepts
PhosphorylationTroponin ISarcomereMyofilamentProtein kinase ATroponinDephosphorylationTroponin CMyosinBiophysicsProtein phosphorylationChemistryBiochemistryBiologyCell biologyInternal medicineMyocytePhosphataseMedicineMyocardial infarctionCardiomyopathy and Myosin StudiesCardiovascular Effects of ExerciseIon channel regulation and function