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Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice

David Kung‐Chun Chiu, Vincent Wai‐Hin Yuen, Jacinth Wing‐Sum Cheu, Larry Lai Wei, Vox Ting, Michael Fehlings, Hermi Sumatoh, Alessandra Nardin, Evan W. Newell, Irene Oi‐Lin Ng, Thomas Yau, Chun‐Ming Wong, Carmen Chak‐Lui Wong

2020Gastroenterology166 citationsDOI

Topics & Concepts

TIGITCytotoxic T cellCancer researchCD8ImmunohistochemistryBiologyMolecular biologyFlow cytometryImmunologyImmune systemIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy research
Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice | Litcius