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PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury

Jiajie Leng, Zhenrui Cao, Letai Li, Dingheng Hu, Yuxiang Luo, Bin Tu, Xiaoying Cao, Rui Tao, Yingjiu Jiang, Hongtao Tie

2025Inflammation Research7 citationsDOIOpen Access PDF

Topics & Concepts

Macrophage polarizationChemistryRegulatorInflammationCell biologyMacrophageImmune systemEnergy metabolismMitochondrionMetabolismSignal transductionInnate immune systemEffectorCell metabolismImmunologyDual roleM2 MacrophageCellular metabolismReactive oxygen speciesPhagolysosomeArginaseDownregulation and upregulationAllergyBiochemistrySirtuinPharmacologyImmune cells in cancerCardiac Fibrosis and RemodelingNF-κB Signaling Pathways
PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury | Litcius