Structure-based optimizations of a necroptosis inhibitor (SZM594) as novel protective agents of acute lung injury
Lijuan Xu, Ye Tu, Jiao Li, Wannian Zhang, Zhibin Wang, Chunlin Zhuang, Lei Xue
Topics & Concepts
NecroptosisRIPK1ChemistryBenzothiazoleTumor necrosis factor alphaProtein kinase AEfferocytosisKinasePharmacologyProgrammed cell deathBiochemistryMacrophageApoptosisMedicineIn vitroImmunologyCell death mechanisms and regulationImmune Response and Inflammationinterferon and immune responses