Quantitative Phosphoproteomics Reveals Extensive Protein Phosphorylation Dysregulation in the Cerebral Cortex of Huntington’s Disease Mice Prior to Onset of Symptoms
Isaline Mees, Harvey Tran, Anne M. Roberts, Larissa Lago, Shanshan Li, Blaine R. Roberts, Anthony J. Hannan, Thibault Renoir
Topics & Concepts
PhosphorylationBiologyPhosphoproteomicsHuntingtinCell biologyProtein phosphorylationPolyglutamine tractGenetically modified mouseHuntingtin ProteinTransgeneProtein kinase AGeneGeneticsMutantGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyNeurological disorders and treatments