Gold nanoclusters as a GSH activated mitochondrial targeting photosensitizer for efficient treatment of malignant tumors
Chen Fan, Shuyang Zhai, Wei Hu, Siyu Chi, Dan Song, Zhihong Liu
Abstract
This is the first example of mitochondrial targeting Au NCs capable of improving the efficiency of photodynamic therapy. Mito-Au<sub>25</sub>@MnO<sub>2</sub> can be activated by consuming GSH and elevating oxidation pressure in cancer cells.
Topics & Concepts
NanoclustersPhotosensitizerPhotodynamic therapyMitochondrionCancer researchChemistryGlutathioneCancer therapyCancerPhotochemistryBiochemistryMedicineInternal medicineOrganic chemistryEnzymeNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranostics