A mitochondrial-targeting iridium(<scp>iii</scp>) complex for H<sub>2</sub>O<sub>2</sub>-responsive and oxidative stress amplified two-photon photodynamic therapy
Xinxing Liao, Jinchao Shen, Weijun Wu, Shi Kuang, Ming‐Wei Lin, Johannes Karges, Zilong Tang, Hui Chao
Abstract
The mitochondrial-targeting iridium( iii ) complex Ir–B(OH)2 is activated in the presence of endogenous H 2 O 2 to release the two-photon photosensitizer Ir–OH and the GSH scavenger methylquinone for amplified two-photon photodynamic therapy.
Topics & Concepts
IridiumPhotosensitizerOxidative stressChemistryPhotodynamic therapyMitochondrionOxidative phosphorylationGlutathioneEndogenyPhotochemistryBiophysicsBiochemistryBiologyEnzymeCatalysisOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry