Development of PROTAC degrader probe of CDK4/6 based on DCAF16
Chunlan Pu, Yuanyuan Liu, Rui Deng, Qingjia Xu, Shirui Wang, Hongjia Zhang, Dan Luo, Xinyu Ma, Yu Tong, Rui Li
Topics & Concepts
PalbociclibCyclin-dependent kinaseChemistryBreast cancerCancer researchUbiquitin ligaseTriple-negative breast cancerCancerKinaseCyclin-dependent kinase 4Cell cycleMalignancyCyclinUbiquitinCellCyclin-dependent kinase 2BiochemistryInternal medicineBiologyMetastatic breast cancerMedicineGeneProtein Degradation and InhibitorsAdvanced Breast Cancer TherapiesUbiquitin and proteasome pathways