Synthesis of Trifluoromethyl- and Ester Group-Substituted α-Carbolines via Iron-Catalyzed Tandem Cyclization Reaction
Yumin Xu, Xiaoqian Chen, Yiqin Gao, Zicong Yan, Changfeng Wan, Jin‐Biao Liu, Zhiyong Wang
Abstract
An efficient approach to prepare trifluoromethyl-α-carbolines and ester group-substituted α-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones or β,γ-unsaturated α-ketoesters was reported. The transformation proceeded smoothly in the presence of catalytic environmental-benign iron salts, which are used to prepare the desired products in moderate to good yields.
Topics & Concepts
ChemistryTrifluoromethylAcetonitrilesTandemCatalysisGroup (periodic table)Medicinal chemistryOrganic chemistryCombinatorial chemistryAcetonitrileAlkylMaterials scienceComposite materialFluorine in Organic ChemistryAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods