Bacterial cellulose-FucoPol composite hydrogel dressings for advanced wound treatment
Asiyah Esmail, Ana Rovisco, Maria Morais, Ana Pimentel, Elvira Fortunato, Teresa Serra, Filomena Freitas
Abstract
as a crosslinking agent. Increasing FP concentration (1.0, 1.5, 2.0 wt%) improved the composite's mechanical strength, but reduced its crystallinity index (43-38 %), water holding capacity (72-39 g/g) and water retention, compared to BC by itself (crystallinity index: 59 %; water holding capacity: 123 g/g). The BC/FP composite dressings (containing 13-25 % FP) demonstrated non-cytotoxicity, with cell viability exceeding 80 % in HaCaT cells (human skin keratinocytes) and NCTC clone L929 (mouse fibroblast) cell lines, and enhanced both cell lines' adhesion, thus supporting their suitability for active wound dressing applications.
Topics & Concepts
Bacterial celluloseCelluloseComposite numberSelf-healing hydrogelsChemistryWound healingChemical engineeringMaterials scienceComposite materialMedicinePolymer chemistrySurgeryOrganic chemistryEngineeringAdvanced Cellulose Research StudiesWound Healing and TreatmentsElectrospun Nanofibers in Biomedical Applications