In missed abortion the decrease of IGF-1 down-regulates PI3K/AKT signaling pathway reducing the secretion of progesterone and β-hCG
Weitao Liang, Tianyuan Zhu, Na Tan, Guangzhuang Jing, Li’ao Xie, Yuhui Dang, Zhilan Li
Topics & Concepts
TrophoblastPI3K/AKT/mTOR pathwayProtein kinase BApoptosisAbortionEndocrinologySignal transductionSecretionMedicineInternal medicinePregnancyBiologyFetusCell biologyPlacentaBiochemistryGeneticsGrowth Hormone and Insulin-like Growth FactorsReproductive System and PregnancyOvarian function and disorders