6-PPD quinone reduces lifespan by activating a feedback loop between cholesterol transformation related signal and insulin signaling in Caenorhabditis elegans
Yuxing Wang, Guocheng Hu, Dayong Wang, Dayong Wang
Topics & Concepts
RNA interferenceCholesterolTransformation (genetics)ChemistryCaenorhabditis elegansCell biologyInsulinInsulin receptorSignal transductionReceptorGeneDownregulation and upregulationBiologyBiochemistryLiver X receptorEndocrinologyGene expressionInternal medicineLigand (biochemistry)PharmacologyRegulation of gene expressionLipid metabolismTransgeneInsulin resistanceMetabolismGenetics, Aging, and Longevity in Model OrganismsHormonal Regulation and HypertensionTryptophan and brain disorders