Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases
Rodrigo Boscariol, José Martins de Oliveira, Denicezar Ângelo Baldo, Victor M. Balcão, Marta M. D. C. Vila
Abstract
The transdermal permeation of curcumin aided by choline and geranic acid ionic liquid (CAGE-IL) was addressed as a potential treatment for skin diseases. An in-depth analysis of the effect of CAGE-IL concentration in the enhancement of transdermal permeation of curcumin was performed, and the results were modelled via nonlinear regression analysis. The results obtained showed that a low percentage of CAGE-IL (viz. 2.0%, w/w) was effective in disrupting the skin structure in a transient fashion, facilitating the passage of curcumin dissolved in it.
Topics & Concepts
CurcuminTransdermalPermeationChemistryPharmacologyChromatographyMedicineBiochemistryMembraneCurcumin's Biomedical ApplicationsPhytochemicals and Antioxidant ActivitiesAdvancements in Transdermal Drug Delivery