HDAC6-specific inhibitor suppresses Th17 cell function via the HIF-1α pathway in acute lung allograft rejection in mice
Wenyong Zhou, Jun Yang, Gaowa Saren, Heng Zhao, Kejian Cao, Shijie Fu, Xufeng Pan, Huijun Zhang, An Wang, Xiaofeng Chen
Abstract
These findings suggest that Tubastatin A downregulates Th17 cell function and suppresses acute lung allograft rejection, at least partially, via the HIF-1α/ RORγt pathway.
Topics & Concepts
LungHDAC6Cancer researchFunction (biology)CellMedicineChemistryCell biologyBiologyInternal medicineBiochemistryGeneHistoneHistone deacetylaseHistone Deacetylase Inhibitors ResearchAdenosine and Purinergic SignalingPeptidase Inhibition and Analysis