Landscape of Non-canonical Cysteines in Human VH Repertoire Revealed by Immunogenetic Analysis
Ponraj Prabakaran, Partha S. Chowdhury
Abstract
s, which are reminiscent of and more complex than those found in other non-human species such as chicken, camel, llama, shark, and cow. These results explain how non-canonical cysteines strategically occur in the human antibodyome to expand its paratope space. This study will guide the design of human antibodies harboring disulfide-stabilized long CDR-H3s to access difficult-to-target epitopes and influence a paradigm shift in developability involving non-canonical cysteines.
Topics & Concepts
ParatopeComplementarity determining regionRepertoireComplementarity (molecular biology)Canonical correlationComputational biologyBiologyAntibody RepertoireEpitopeEvolutionary biologyGeneticsAntibodyImmunoglobulin light chainComputer scienceArtificial intelligenceAcousticsPhysicsMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyGlycosylation and Glycoproteins Research