APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis
Joana Fernandes da Rocha, Luísa Bastos, Sara C. Domingues, Ana Rita Bento, Uwe Konietzko, Odete A. B. da Cruz e Silva, Sandra I. Vieira
Topics & Concepts
Epidermal growth factorImmunoprecipitationNeuriteHeparin-binding EGF-like growth factorMAPK/ERK pathwayCell biologyAmyloid precursor proteinNeurogenesisNeurotrophinNeurotrophic factorsSignal transductionBiologyChemistryMolecular biologyReceptorAlzheimer's diseaseInternal medicineBiochemistryImmunologyMedicineAntibodyDiseaseIn vitroAlzheimer's disease research and treatments14-3-3 protein interactionsGlycosylation and Glycoproteins Research