A novel ligand-modified nanocomposite microparticles improved efficiency of quercetin and paclitaxel delivery in the non-small cell lung cancer
Xiao-Ming Cui, Fang Zhang, Yanyan Zhao, Pan Li, Ting Wang, Zhilu Xu, Jingjing Zhang, Weifen Zhang
Abstract
analysis results presented that P/Q@CNMPs have the accuracy targeting ability and killing effect on non-small cell lung cancer (NSCLC) which express positive epidermal growth factor receptor (EGFR) on the membrane. Furthermore, this system also has low toxicity and good biocompatibility. These results demonstrated that P/Q@CNMPs could be a potential intelligent targeting strategy used for chemo-resistant NSCLC therapies.
Topics & Concepts
PaclitaxelCetuximabIn vivoPharmacologyLung cancerEpidermal growth factor receptorMaterials scienceDrug deliveryBiocompatibilityChemotherapyCancer researchCancerMedicineNanotechnologyOncologyBiologyInternal medicineBiotechnologyMetallurgyColorectal cancerNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug DeliveryDendrimers and Hyperbranched Polymers