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Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF

Sandi Radko-Juettner, Hong Yue, Jacquelyn Myers, Raymond D. Carter, Alexis Robertson, Priya Mittal, Zhexin Zhu, Baranda S. Hansen, Katherine A. Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan McReynolds, Shourya S. Roy Burman, Anna M. Schmoker, Nada Mageed, Scott A. Brown, Robert J. Mobley, Janet F. Partridge, Elizabeth Stewart, Shondra M. Pruett‐Miller, Behnam Nabet, Junmin Peng, Nathanael S. Gray, Eric S. Fischer, Charles W.M. Roberts

2024Nature59 citationsDOIOpen Access PDF

Topics & Concepts

SMARCB1SWI/SNFSMARCA4MutantSuppressorCancer researchARID1ABiologyMutationCell biologyGeneticsCancerGeneChromatinChromatin remodelingChromatin Remodeling and CancerCancer Mechanisms and TherapyProtein Degradation and Inhibitors
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF | Litcius