TRPV1 enhances cholecystokinin signaling in primary vagal afferent neurons and mediates the central effects on spontaneous glutamate release in the NTS
Rachel A. Arnold, Daniel K. Fowler, James H. Peters
Abstract
Cholecystokinin (CCK) signaling via the vagus nerve reduces food intake and produces satiation, yet the signaling cascades mediating these effects remain unknown. Here we report that the capsaicin receptor transient receptor potential vanilloid subtype 1 (TRPV1) potentiates CCK signaling in the vagus and mediates the ability of CCK to control excitatory synaptic transmission in the nucleus of the solitary tract. These results may prove useful in the future development of CCK/TRPV1-based therapeutic interventions.
Topics & Concepts
TRPV1CholecystokininSolitary tractNeuroscienceExcitatory postsynaptic potentialVagus nerveGlutamate receptorTransient receptor potential channelNeurotransmissionCapsaicinChemistryCholecystokinin receptorSignal transductionReceptorNucleusCell biologyBiologyInhibitory postsynaptic potentialStimulationBiochemistryIon Channels and ReceptorsNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research