Site-specific albumin tagging with NIR-II fluorogenic dye for high-performance and super-stable bioimaging
Ningning Zhu, Jiajun Xu, Qi Su, Tianyang Han, Ding Zhou, Yuewei Zhang, Shoujun Zhu
Abstract
Our cyanine@albumin probe substantially improves the pharmacokinetics of its free dye counterpart, enabling high-performance NIR-II angiography and lymphography. Importantly, the site-specific labeling tags between NIR-II fluorogenic dyes and albumin occur under mild conditions, offering a specific and straightforward synthesis strategy for NIR-II fluorophores in the fields of targeting bioimaging and imaging-guided surgery.
Topics & Concepts
CyanineAlbuminChemistryBiomoleculeCombinatorial chemistryBiophysicsCovalent bondBovine serum albuminFluorescenceChromatographyBiochemistryOrganic chemistryBiologyQuantum mechanicsPhysicsNanoplatforms for cancer theranosticsAdvanced Biosensing Techniques and ApplicationsNanoparticle-Based Drug Delivery