Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes
Andrew Varble, Edmondo Campisi, Chad W. Euler, Pascal Maguin, Albina Kozlova, Jessica Fyodorova, Jakob T. Rostøl, Vincent A. Fischetti, Luciano A. Marraffini
Topics & Concepts
CRISPRProphageBiologyTrans-activating crRNACas9GeneticsStreptococcus pyogenesCRISPR interferencePlasmidAcquired immune systemGeneBacteriophageImmune systemBacteriaEscherichia coliStaphylococcus aureusCRISPR and Genetic EngineeringBacteriophages and microbial interactionsRNA and protein synthesis mechanisms