cRGD-targeted gold-based nanoparticles overcome EGFR-TKI resistance of NSCLC <i>via</i> low-temperature photothermal therapy combined with sonodynamic therapy
Wenhao Lv, Hao Wu, Yao Zhang, Hui Li, Hong Shu, Chunhong Su, Yangyang Zhu, Ting Wang, Fang Nie
Abstract
cRGD-targeted gold-based nanoparticles inhibit the TGF-β/PDLIM5/SMAD signaling pathway to overcome EGFR-TKI resistance in NSCLC via low-temperature photothermal therapy combined with sonodynamic therapy.
Topics & Concepts
GefitinibSonodynamic therapyPhotothermal therapyCancer researchIn vivoEpidermal growth factor receptorTargeted therapyApoptosisPharmacologyChemistryMedicineCancerMaterials scienceReceptorNanotechnologyInternal medicineBiochemistryBiologyBiotechnologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryLung Cancer Research Studies