Synthetic nanointerfacial bioengineering of Ti implants: on-demand regulation of implant–bone interactions for enhancing osseointegration
Yilong Dong, Yan Hu, Xinqiang Hu, Lingshuang Wang, Xinkun Shen, Hao Tian, Menghuan Li, Zhong Luo, Chun-Yuan Cai
Abstract
. In this review, we provide a comprehensive analysis on the state-of-the-art synthetic nanointerfacial bioengineering strategies for designing Ti-based biofunctional orthopedic implants, with special emphasis on the contributions to (1) promotion of new bone formation and binding at the implant-bone interface, (2) bacterial elimination for preventing peri-implant infection and (3) overcoming osseointegration resistance induced by degenerative bone diseases. Furthermore, a perspective is included to discuss the challenges and potential opportunities for the interfacial engineering of Ti implants in a translational perspective. Overall, it is envisioned that the insights in this review may guide future research in the area of biometallic orthopedic implants for improving bone repair with enhanced efficacy and safety.