Organocatalytic asymmetric cascade bicyclization: access to chiral polycyclic bisindoles from 2-indolylmethanols and propargylic alcohols
Wen-Run Zhu, Qiong Su, Xiaoyi Deng, Ze-Long Ouyang, Jiang Weng, Gui Lu
Abstract
A chiral phosphoric acid-catalyzed asymmetric bis-cyclization of α-indolyl propargylic alcohols with 2-indolylmethanols was realized.
Topics & Concepts
ChemistryCascadeCombinatorial chemistryChromatographyAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality SynthesisChemical synthesis and alkaloids