Nickel-Catalyzed Reductive Csp<sup>2</sup>–Csp<sup>3</sup> Cross Coupling Using Phosphonium Salts
Huifei Wang, Mengwan Yang, Yu‐Ting Wang, Xi Man, Xinyao Lu, Zehuai Mou, Yunjie Luo, Hongze Liang
Abstract
A nickel-catalyzed reductive cross coupling with phosphonium salts and allylic C(sp3)–O bond electrophiles, which granted direct construction of the C(sp2)–C(sp3) bond, is successfully developed. The protocol features broad substrate scope, high-functional-group tolerance, and heterocycle compatibility. Notably, the much more challenging reductive cross coupling with heterocyclic thiazolylphosphonium salts has also been accomplished for the first time.
Topics & Concepts
PhosphoniumChemistryElectrophileNickelCatalysisReagentAllylic rearrangementCombinatorial chemistryFunctional groupMedicinal chemistryPolymer chemistryOrganic chemistryPolymerCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions