Identification of thienopyrimidine derivatives tethered with sulfonamide and other moieties as carbonic anhydrase inhibitors: Design, synthesis and anti-proliferative activity
Samah Higazy, Nermin Samir, Ahmed El‐Khouly, Simone Giovannuzzi, Paloma Begines, Hatem M. Gaber, Claudiu T. Supuran, Khaled A. M. Abouzid
Topics & Concepts
ChemistryCarbonic anhydraseGene isoformGrowth inhibitionEnzymeCell cultureCarbonic anhydrase IIStereochemistryDocking (animal)Cell growthIsozymeBiochemistryGeneMedicineBiologyGeneticsNursingEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities